Online Liposome Extrusion System
This online liposome extruder is a high-throughput extrusion system developed to meet the large-scale GMP requirements of liposome production. The core extrusion plate is made of sanitary-grade 316L stainless steel that complies with FDA and GMP standards, containing laser-drilled micro-sized pores as membrane supports. This extruder can be integrated with manual pumps, electric pumps, high-pressure homogenizers, or air pumps, operating at pressures from 1500–5000 psi. It is mainly used in the homogenization of pharmaceutical-grade liposomes, emulsions, and nanoparticles, used with a track-etched filter membrane with pore sizes of 50–400 nm. This extruder can be used to produce formulations of doxorubicin, paclitaxel, amphotericin B, daunorubicin, cytarabine, vincristine, cisplatin, and econazole nitrate liposomes.
| Models | |||||
|---|---|---|---|---|---|
| Working Pressure (psi) | 0-4500 | 0-4500 | 0-4500 | 0-7500 | 0-7500 |
| Capacity | Laboratory online type | Pilot-scale | Industrial-scale | Industrial-scale | Industrial-scale |
| Membrane Filter Diameter (mm) | 47 | 90 | 142 | 142 | 293 |
- All component materials, including O-rings and gaskets, are FDA certified
- Wetted part contact pipelines are made of 316L stainless steel
- GMP-compliant, suitable for cleanroom use
- Support CIP and SIP cleaning
The online liposome extrusion system works by repeatedly passing multilamellar liposome suspensions through polycarbonate membranes with predefined nanopores, producing unilamellar liposomes and nucleic acids in uniform and smaller particles.